![]() ![]() They manage the City of Fort Worth’s nine sister city relationships around the world, from Nagaoka, Japan to Toluca, Mexico. Funding Needsįort Worth Sister Cities International promotes Fort Worth globally and enriches our community through international education, exchange and commerce, creating a more peaceful and prosperous world. This particular research project has been selected by a group of local NTCF donors who desire to fund research and give hope to those suffering from Alzheimer’s and Dementia. Herz will study the effectiveness, mechanism, and safety of inhibiting NHE6 to reduce the risk of Alzheimer’s associated with the APOE-e4 gene variation. Inhibiting or reducing a protein called NHE6 corrected these defects and reduced the abnormal accumulation of plaque. In previous research, Joachim Herz, M.D., has found that APOE-e4 causes defects in how materials are moved in and out of cells. The abnormal accumulation of plaques is a hallmark brain change of Alzheimer’s because the brain loses its ability to clear plaques effectively. ![]() ![]() Possessing the APOE-e4 gene is believed to impact the risk of developing Alzheimer’s in some populations. The E (APOE) gene provides instructions for making APOE proteins thought to help carry fats throughout the body. Some research projects are approved by AA but require private funding. Alzheimer’s Association supports many research projects but do not have funding to support every research project proposed. In Tarrant County, where Alzheimer’s is the fifth leading cause of death, the North Central Chapter continues to be a leader in the community in providing support to families, caregivers and professionals affected by this devastating disease. The Alzheimer’s Association’s mission is to accelerate global research, drive risk reduction and early detection, and maximize quality care. ![]()
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